Encouraging results from a Phase II Trial in patients with AML and ALL
CellCAN is proud to relay this press release from Kiadis Pharma.
Kiadis Pharma presents positive data on the primary endpoint of its single dose
Phase II trial with ATIR101TM
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Significant increase in Overall Survival and reduction in Transplant Related Mortality observed in comparison
to a historical control group
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Zero patients developed grade III-IV acute Graft-versus-Host-Disease upon infusion of ATIR101TM
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Initiation of a randomised Phase III trial in the second half of 2016
Amsterdam, The Netherlands, April 4, 2016, – Kiadis Pharma N.V. (“Kiadis Pharma” or the “Company”) (Euronext Amsterdam and Brussels: KDS), a clinical stage biopharmaceutical company developing innovative T-cell immunotherapy treatments for blood cancers and inherited blood disorders, today presents positive results on the primary endpoint of its single dose Phase II trial (NCT01794299/EudraCT 2012-004461-41) with its lead product ATIR101TM at the 42nd Annual Meeting of the European Society of Blood and Marrow Transplantation (EBMT) in Valencia, Spain.
The data presented in session O042 by Dr. Denis-Claude Roy, Professor of Medicine at the University of Montreal and the principal investigator for the trial, confirms that ATIR101TM can be safely infused, does not cause grade III-IV Graft-versus-Host-Disease (GVHD) and shows a significant reduction in Transplant Related Mortality (TRM) and a significant improvement in Overall Survival (OS) in comparison to a historical control group of patients undergoing a T-cell depleted haploidentical donor transplantation only.
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Donor lymphocytes depleted of alloreactive T-cells (ATIR101TM) improve overall survival and reduce transplant related mortality in a T-cell depleted haploidentical HSCT: Results from a Phase 2 Trial in patients with AML and ALL
Leukemia-associated antigen reactive T-cells in ATIR101TM, a recipient-specific allodepleted T-cell product facilitating haploidentical HSCT
Effect of graft source on safety and efficacy in patients undergoing hematopoietic stem cell transplantation
An exploratory, open-label, multicenter study to evaluate safety and efficacy of a two-dose regimen of ATIR101TM in
patients with a hematologic malignancy, who received a CD34-selected hematopoietic stem cell transplantation from
a haploidentical donor